Pearl Frush was born in Iowa, although she and her family moved to the Gulf Coast of Mississippi when she was still a child. She enrolled in art instruction courses New Orleans before moving on to study in Philidelphia and New York. By this time her family had moved to Chicago, where she joined them after enrolling at the Chicago Art Institute.

Frush opened her Chicago studio in the early 1940's, doing freelance work and working for the Sundblom, Johnson and White Studio. By 1943 she was working for the Gerlach-Barklow Calendar Company, producing a popular series of work such as: Liberty Belles, Girls of Glamour and Glamour round the Clock. It wasn't until 1955 that Brown and Bigelow started producing calendars of her work, however she soon became one of the most successful female pinup artists of the fifties.

Pearl Frush's work was painted primarily in watercolours and gouache, and her crisp detailed style is reminicent of Vargas's work. Her subjects are often more gracefully portrayed and less overtly sexual than other artists work of the time.