Roy Fox Lichtenstein was one of the first American Pop artists to achieve widespread renown, and he became a lightning rod for criticism of the movement. His early work ranged widely in style and subject matter, and displayed considerable understanding of modernist painting: Lichtenstein would often maintain that he was as interested in the abstract qualities of his images as he was in their subject matter. However, the mature Pop style he arrived at in 1961, which was inspired by comic strips, was greeted by accusations of banality, lack of originality, and, later, even copying. His high-impact, iconic images have since become synonymous with Pop art, and his method of creating images, which blended aspects of mechanical reproduction and drawing by hand, has become central to critics' understanding of the significance of the movement.

Roy Lichtenstein played a critical role in subverting the skeptical view of commercial styles and subjects established by the Abstract Expressionists. By embracing "low" art such as comic books and popular illustration, Lichtenstein became one of the most important figures in the Pop art movement. While his paintings of cartoons and comics are his most recognizable work, he had a prolific and somewhat eclectic career that drew from Cubism, Surrealism, and Expressionism. But it is his re-imagining of popular culture through the lens of traditional art history that has remained a considerable influence to later generations of artists, as Pop art went on to significantly inform Postmodernism.